Gillette T E, Chandler J W, Greiner J V
Ophthalmology. 1982 Jun;89(6):700-11. doi: 10.1016/s0161-6420(82)34737-5.
Recent evidence has been collected by several investigators defining a distinct population of dendritic cells (Langerhans cells) of mesenchymal origin residing in the epidermal surfaces of many mammalian species. These cells play a dominant role in the processing of antigens presented through cutaneous surfaces and carry a Class II histocompatability antigen felt to be of central importance in the afferent arm of allograft rejection. They also possess many of the characteristics of macrophages active in the efferent arm of immunologic responses. An equivalent subset of dendritic cells (Langerhans cells) in ocular surface epithelium of the human, mouse rat, and guinea pig has been identified by enzyme histochemistry, immunofluorescence, and electron microscopy. Ocular surface Langerhans cells proliferate in the setting of corneal inflammation (remote and recent) and are depleted by topical and systemic corticosteroids. Ocular surface Langerhans cells may play a central role in ocular contact hypersensitivity, corneal allograft rejection, and ocular surface immune surveillance.
几位研究人员最近收集的证据表明，在许多哺乳动物物种的表皮表面存在一群独特的间充质来源的树突状细胞（朗格汉斯细胞）。这些细胞在通过皮肤表面呈递的抗原处理过程中起主导作用，并携带一种II类组织相容性抗原，该抗原被认为在同种异体移植排斥反应的传入臂中至关重要。它们还具有许多在免疫反应传出臂中活跃的巨噬细胞的特征。通过酶组织化学、免疫荧光和电子显微镜已鉴定出人类、小鼠、大鼠和豚鼠眼表上皮中树突状细胞（朗格汉斯细胞）的等效亚群。眼表朗格汉斯细胞在角膜炎症（近期和远期）情况下增殖，并被局部和全身皮质类固醇消耗。眼表朗格汉斯细胞可能在眼部接触性超敏反应、角膜移植排斥反应和眼表免疫监视中起核心作用。
