Warren K S
Rev Infect Dis. 1982 May-Jun;4(3):715-26. doi: 10.1093/clinids/4.3.715.
The control of schistosomiasis should be related to its unique biology and ecology. Whereas schistosomes multiply within the snail intermediate host, they do not replicate within the mammalian definitive host. As a consequence, a large proportion of infected humans have low or moderate worm burdens, the disease tending to occur in the small proportion of individuals harboring large numbers of worms. This situation suggests an unusual strategy: the control of schistosomal disease rather than the usual approach of control of infection and its almost invariable end point of eradication. Control of infection (transmission) requires use of mollusciciding, provision of water supplies and sanitation, health education, and chemotherapy and is still highly unlikely to result in eradication. Control of disease can be achieved at far lower cost by chemotherapy alone using the newer single-dose, oral, nontoxic chemotherapeutic agents.
血吸虫病的控制应与其独特的生物学和生态学相关。血吸虫在中间宿主蜗牛体内繁殖，但在哺乳动物终宿主内不进行复制。因此，很大一部分受感染的人虫负荷较低或中等，疾病往往发生在少数携带大量蠕虫的个体中。这种情况表明了一种不同寻常的策略：控制血吸虫病，而不是采用控制感染及其几乎不变的根除终点的常规方法。控制感染（传播）需要使用杀螺剂、提供供水和卫生设施、进行健康教育以及化疗，而且仍然极不可能实现根除。仅使用更新的单剂量、口服、无毒化疗药物进行化疗，就能以低得多的成本实现疾病控制。
