Klingler D, Trägner H
Wien Med Wochenschr. 1982 Jun 15;132(11):263-7.
Of 901 patients investigated 167 showed a focal disturbance in the EEG before and/or after 24-hours sleep deprivation. 459 patients suffered from epileptic seizures, the remainder had non-epileptic attacks or an organic cerebral disease without seizures. Of the 167 focal EEG changes 21.6% were seen only following sleep deprivation. In 9.6% focal changes present before could not be observed anymore following sleep deprivation. There was no significant difference between the three groups of patients mentioned above. The 24-hours sleep deprivation thus represents an activation procedure which may enhance diagnostic information relating to the question of focal EEG disturbances not only in epileptic patients. In the group of patients with epileptic seizures the activation or suppression respectively of the focal disturbance showed some dependence from seizure type and frequency as well as from the type of the focal change (spikes or slow waves). In our material the differences were however not statistically significant. More information could be gained from the waking EEG and from stage 1 than from sleeping stages 2 to 4 according to Rechtschaffen and Kales. Trigger functions could be attributed especially to the transitional phases from wakefulness to sleep and from stage 1 to stage 2 and vice versa particularly associated with arousal reactions. In our short sleep records REM stages could be rarely observed.
在接受调查的901名患者中，167名在24小时睡眠剥夺之前和/或之后脑电图显示局灶性异常。459名患者患有癫痫发作，其余患者有非癫痫发作或无癫痫发作的器质性脑部疾病。在167例脑电图局灶性改变中，21.6%仅在睡眠剥夺后出现。9.6%的患者在睡眠剥夺前存在的局灶性改变在睡眠剥夺后未再观察到。上述三组患者之间无显著差异。因此，24小时睡眠剥夺是一种激活程序，不仅可以增强癫痫患者局灶性脑电图异常问题的诊断信息。在癫痫发作患者组中，局灶性异常的激活或抑制分别与癫痫发作类型和频率以及局灶性改变类型（棘波或慢波）有关。然而，在我们的资料中，这些差异无统计学意义。根据Rechtschaffen和Kales的研究，从清醒脑电图和第1阶段比从睡眠第2至4阶段可获得更多信息。触发功能尤其可归因于从清醒到睡眠以及从第1阶段到第2阶段的过渡阶段，反之亦然，尤其与唤醒反应有关。在我们的短睡眠记录中，很少观察到快速眼动睡眠阶段。
