Bapurao S, Raman L, Tulpule P G
Am J Clin Nutr. 1982 Oct;36(4):581-6. doi: 10.1093/ajcn/36.4.581.
Two groups of pregnant women belonging to a low socioeconomic group, one with oral lesions and the other without lesions, were studied in the 3rd trimester of pregnancy for vitamin B6 nutritional status. Both the groups showed evidence of abnormal tryptophan metabolism, and in pregnant women with clinical signs the postload xanthurenic acid excretion in urine was higher than in the other group, suggesting a severe deficiency of vitamin B6. Treatment with vitamin B6 cured the oral lesions and also corrected the abnormalities in tryptophan metabolism. Excretion of 4-pyridoxic acid was low in both the groups and more so in women with oral lesions. Administration of tryptophan load significantly elevated the excretion of 4-pyridoxic acid in urine. These results indicated that pregnant women belonging to a low socioeconomic group were, in general, deficient in vitamin B6. In pregnant women with oral lesions the deficiency of vitamin B6 was more severe than in those pregnant women without oral lesions. Whether the severity of vitamin B6 deficiency would precipitate clinical signs like oral lesions is not yet known.
对两组社会经济地位较低的孕妇进行了研究，一组有口腔病变，另一组没有病变，在妊娠晚期检测她们的维生素B6营养状况。两组均显示出色氨酸代谢异常的迹象，有临床症状的孕妇尿中负荷后黄尿酸排泄量高于另一组，提示维生素B6严重缺乏。用维生素B6治疗可治愈口腔病变，并纠正色氨酸代谢异常。两组中4-吡哆酸的排泄量均较低，有口腔病变的女性更低。给予色氨酸负荷后，尿中4-吡哆酸的排泄量显著升高。这些结果表明，社会经济地位较低的孕妇总体上缺乏维生素B6。有口腔病变的孕妇维生素B6缺乏比无口腔病变的孕妇更严重。维生素B6缺乏的严重程度是否会引发如口腔病变等临床症状尚不清楚。
