Anderson T J, Ferguson D J, Raab G M
Br J Cancer. 1982 Sep;46(3):376-82. doi: 10.1038/bjc.1982.213.
Morphological identification of cell multiplication (mitosis) and cell deletion (apoptosis) within the lobules of the "resting" human breast is used to assess the response of the breast parenchyma to the menstrual cycle. The responses are shown to have a biorhythm in phase with the menstrual cycle, with a 3-day separation of the mitotic and apoptotic peaks. The study fails to demonstrate significant differences in the responses between groups defined according to parity, contraceptive-pill use or presence of fibroadenoma. However, significant differences are found in the apoptotic response according to age and laterality. The results highlight the complexity of modulating influences on breast parenchymal turnover in the "resting" state, and prompt the investigation of other factors as well as steroid hormones and prolactin in the promotion of mitosis. The factors promoting apoptosis in the breast are still not clear.
通过对“静止”状态下人类乳腺小叶内细胞增殖（有丝分裂）和细胞缺失（凋亡）进行形态学鉴定，来评估乳腺实质对月经周期的反应。结果显示，这些反应具有与月经周期同步的生物节律，有丝分裂和凋亡高峰相隔3天。该研究未能证明根据生育状况、是否使用避孕药或是否存在纤维腺瘤所定义的组间反应存在显著差异。然而，根据年龄和乳腺侧别，凋亡反应存在显著差异。这些结果突出了在“静止”状态下调节对乳腺实质更新影响的复杂性，并促使人们研究除类固醇激素和催乳素之外促进有丝分裂的其他因素。促进乳腺细胞凋亡的因素仍不明确。
