Bálint Z, Holczinger L, Szikla K
Bull Cancer. 1982;69(2):138-42.
Incorporation in vivo of 3H-cholesterol into chromatin and its distribution among chromatin subfractions (DNA, histone, nonhistone proteins) of Ehrlich ascites tumour cells were studied. The majority of labeling appeared in the nonhistone fraction and only a slight incorporation or tracer amounts of 3H-labeling was found in the histone and DNA fractions. The 3H-labeling from 3H-cholesterol appeared predominantly in the non esterified cholesterol fractions. Our suggestion that neutral lipids--besides phospholipids--may also contribute to the regulatory functions of nonhistone chromosomal proteins needs further investigations.
研究了3H-胆固醇在体内掺入艾氏腹水瘤细胞染色质及其在染色质亚组分（DNA、组蛋白、非组蛋白）中的分布。大部分标记出现在非组蛋白部分，而在组蛋白和DNA部分仅发现少量掺入或微量的3H标记。来自3H-胆固醇的3H标记主要出现在非酯化胆固醇部分。我们提出的中性脂质（除磷脂外）也可能有助于非组蛋白染色体蛋白的调节功能这一观点需要进一步研究。
