生长调节素与阿尔茨海默型衰老和痴呆症

Somatomedins in aging and dementia disorders of the Alzheimer type.

作者信息

Sara V R, Hall K, Enzell K, Gardner A, Morawski R, Wetterberg L

出版信息

Neurobiol Aging. 1982 Summer;3(2):117-20. doi: 10.1016/0197-4580(82)90006-9.

Abstract

Serum levels of somatomedins were determined in apparently healthy aged individuals and dementia patients primarily with clinically suspected Alzheimer type disorder. Serum somatomedin values, determined by radioreceptorassay and radioimmunoassay, fell with advancing age in normal subjects. A significant elevation in serum somatomedins was observed in dementia patients. CSF somatomedin levels were also increased in the only two patients with suspected Alzheimer type disease examined. Since somatomedins are believed to act as anabolic hormones, it was suggested that the elevated levels represent a compensatory mechanism to overcome receptor insensitivity in patients with dementia disorders of the Alzheimer type.

摘要

对主要患有临床疑似阿尔茨海默型障碍的明显健康老年人和痴呆症患者测定了血清生长调节素水平。通过放射受体测定法和放射免疫测定法测定的血清生长调节素值在正常受试者中随年龄增长而下降。在痴呆症患者中观察到血清生长调节素显著升高。在所检查的仅有的两名疑似阿尔茨海默型疾病患者中，脑脊液生长调节素水平也升高。由于生长调节素被认为具有合成代谢激素的作用，有人提出升高的水平代表一种补偿机制，以克服阿尔茨海默型痴呆症患者的受体不敏感性。