Powe J E, Short A, Sibbald W J, Driedger A A
Crit Care Med. 1982 Nov;10(11):712-8. doi: 10.1097/00003246-198211000-00003.
The polymorphonuclear leukocyte (PMN) plays an integral role in the development of permeability pulmonary edema associated with the adult respiratory distress syndrome (ARDS). This report describes 3 patients with ARDS secondary to systemic sepsis who demonstrated an abnormal diffuse accumulation of Indium (111In)-labeled PMNs in their lungs, without concomitant clinical or laboratory evidence of a primary chest infection. In one patient, the accumulation of the pulmonary activity during an initial pass suggested that this observation was related to diffuse leukoaggregation within the pulmonary microvasculature. A 4th patient with ARDS was on high-dose corticosteroids at the time of a similar study, and showed no pulmonary accumulation of PMNs, suggesting a possible reason for the reported beneficial effect of corticosteroids in human ARDS.
多形核白细胞（PMN）在与成人呼吸窘迫综合征（ARDS）相关的通透性肺水肿的发展中起着不可或缺的作用。本报告描述了3例继发于全身性脓毒症的ARDS患者，这些患者肺部显示铟（111In）标记的PMN异常弥漫性积聚，而无原发性胸部感染的相关临床或实验室证据。在1例患者中，首次通过时肺部放射性活性的积聚表明该观察结果与肺微血管内弥漫性白细胞聚集有关。第4例ARDS患者在进行类似研究时正在接受大剂量皮质类固醇治疗，未显示PMN在肺部的积聚，提示皮质类固醇对人类ARDS具有有益作用的可能原因。
