Kopelovich L
Exp Cell Biol. 1982;50(5):266-70. doi: 10.1159/000163155.
The present results suggest that studies on the oncogenic potential of normal diploid human cells in vitro should be qualified with respect to the stage of development and genetic constitution. For example, cultured normal human embryo and foreskin cells are phenotypically distinct from normal adult cells (5-65 years). The former appear to grow in culture in a fashion similar to that seen with initiated human mutant cells. They also exhibit a proliferative response pattern to a tumor promoter (TPA) closely resembling that obtained with human tumor cells. Thus, normal embryo and foreskin cells presumably represent a state in development which is genetically unstable, rendering them considerably more susceptible to malignant transformation. This conclusion may hold true with respect to spontaneously occurring tumors as well.
目前的结果表明，关于正常二倍体人类细胞体外致癌潜力的研究，应根据发育阶段和基因构成进行限定。例如，培养的正常人类胚胎细胞和包皮细胞在表型上与正常成人细胞（5至65岁）不同。前者在培养中的生长方式似乎与人类起始突变细胞相似。它们对肿瘤促进剂（TPA）的增殖反应模式也与人类肿瘤细胞非常相似。因此，正常胚胎细胞和包皮细胞可能代表了一种发育中的基因不稳定状态，使它们更容易发生恶性转化。这一结论可能同样适用于自发发生的肿瘤。
