奇加尼霉素（Sch 25663），一种由基贾尼亚马杜拉放线菌SCC 1256产生的新型抗生素。发酵、分离、表征及生物学特性。

Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC 1256. Fermentation, isolation, characterization and biological properties.

作者信息

Waitz J A, Horan A C, Kalyanpur M, Lee B K, Loebenberg D, Marquez J A, Miller G, Patel M G

出版信息

J Antibiot (Tokyo). 1981 Sep;34(9):1101-6. doi: 10.7164/antibiotics.34.1101.

DOI:10.7164/antibiotics.34.1101

Abstract

A novel antibiotic complex has been isolated form the fermentation broth of a new species of Actinomadura, A. kijaniata SCC 1256. The complex was separated form the broth by a solvent extraction procedure and consists of 1 major component, designated kijanimicin, and 3 minor components. Kijanimicin was isolated form the complex by column chromatography and/or preparative high pressure liquid chromatography. Structurally the compound is a unique, large acid enol antibiotic and possesses an unusual in vitro spectrum of activity against some Gram-positive and anaerobic microorganisms. In vivo it has also shown interesting activity against malaria.

摘要

从一种新的马杜拉放线菌（A. kijaniata SCC 1256）的发酵液中分离出了一种新型抗生素复合物。该复合物通过溶剂萃取法从发酵液中分离出来，由1种主要成分（命名为基贾尼霉素）和3种次要成分组成。基贾尼霉素通过柱色谱法和/或制备型高压液相色谱法从该复合物中分离出来。从结构上看，该化合物是一种独特的、大分子酸性烯醇抗生素，对某些革兰氏阳性菌和厌氧微生物具有不同寻常的体外活性谱。在体内，它对疟疾也显示出有趣的活性。