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离子霉素,一种新型聚醚类抗生素。

Ionomycin, a new polyether antibiotic.

作者信息

Liu W C, Slusarchyk D S, Astle G, Trejo W H, Brown W E, Meyers E

出版信息

J Antibiot (Tokyo). 1978 Sep;31(9):815-9. doi: 10.7164/antibiotics.31.815.

Abstract

Ionomycin, a new polyether antibiotic with a high affinity for calcium ions, is obtained in pure form from fermentation broths of Streptomyces conglobatus sp. nov. Trejo by solvent extraction. It is unique amongst known polyether antibiotics in that it has a UV absorption maximum at 300 nm. thereby distinguishing it from other antibiotics of its class. The Ca salt has the molecular formula C41H70O9Ca. Ionomycin is a narrow spectrum antibiotic being active against Gram-positive bacteria.

摘要

离子霉素是一种对钙离子具有高亲和力的新型聚醚抗生素,通过溶剂萃取从球状链霉菌新种Trejo的发酵液中获得纯品。它在已知的聚醚抗生素中独具特色,其紫外吸收峰在300纳米处,从而使其有别于该类别的其他抗生素。钙盐的分子式为C₄₁H₇₀O₉Ca。离子霉素是一种窄谱抗生素,对革兰氏阳性菌有活性。

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