Pentland B, Matthews D, Mawdsley C
Scott Med J. 1982 Oct;27(4):284-7. doi: 10.1177/003693308202700404.
The long-term results of levodopa therapy in Parkinsonian patients is described. Between January 1969 and December 1972, dopaminergic therapy was started in 186 patients with Parkinson's disease. Their progress after six months, five years and in the autumn of 1980, was assessed. The initial benefit in the majority of patients was followed by a gradual loss of efficacy in most patients with increasing side effects of central-mediated type. We suggest that it may be wise to delay the onset of levodopa therapy until progress of the disease makes treatment imperative.
本文描述了帕金森病患者左旋多巴治疗的长期结果。1969年1月至1972年12月期间，对186例帕金森病患者开始了多巴胺能治疗。评估了他们在6个月、5年以及1980年秋季后的病情进展。大多数患者最初受益，但随后大多数患者疗效逐渐丧失，同时中枢介导型副作用增加。我们认为，推迟左旋多巴治疗的开始时间可能是明智的，直到疾病进展使治疗成为必要。
