Wennberg E, Haljamäe H, Edwall G, Dhuner K G
Acta Anaesthesiol Scand. 1982 Oct;26(5):524-7. doi: 10.1111/j.1399-6576.1982.tb01812.x.
Differences in the effects of commercially available, sodium bisulfite-containing (pH 3.5-4), and freshly prepared (pH 6.5) lidocaine-adrenaline solutions on tissue pH and tissue oxygenation were studied experimentally. In rabbits, a 5 x 5 cm area under the panniculum was infiltrated with 0.9% NaCl, plain lidocaine, plain adrenaline or one of the two lidocaine-adrenaline solutions. Tissue pH was measured continuously as well as intermittently in the infiltrated area with monocrystalline antimony needle electrodes. Infiltration of the tissue with the 4 ml volume of a test solution did not seem to induce any significant tissue injury. Tissue pH was decreased for 30 min following plain lidocaine and for 90 min or more following lidocaine-adrenaline infiltration. With the exception of the first few minutes, no significant differences in the effects on tissue pH between commercial and freshly prepared lidocaine-adrenaline solutions could be seen. Tissue hypoxia occurred only following infiltration with plain adrenaline. It may thus be concluded that in spite of the low pH and the O2-reducing properties of commercial lidocaine-adrenaline solutions, a rapid buffering occurs in the tissues. The use of commercial lidocaine-adrenaline solution for local infiltration thus seems as safe as that of freshly prepared lidocaine-adrenaline solutions.
对市售含亚硫酸氢钠（pH 3.5 - 4）和新配制（pH 6.5）的利多卡因 - 肾上腺素溶液对组织pH值和组织氧合作用的差异进行了实验研究。在兔子身上，在皮下组织下5×5平方厘米的区域注射0.9%氯化钠、普通利多卡因、普通肾上腺素或两种利多卡因 - 肾上腺素溶液之一。使用单晶锑针电极在浸润区域连续和间歇地测量组织pH值。用4毫升测试溶液浸润组织似乎不会引起任何明显的组织损伤。普通利多卡因浸润后组织pH值降低30分钟，利多卡因 - 肾上腺素浸润后降低90分钟或更长时间。除最初几分钟外，市售和新配制的利多卡因 - 肾上腺素溶液对组织pH值的影响未见显著差异。仅在注射普通肾上腺素后出现组织缺氧。因此可以得出结论，尽管市售利多卡因 - 肾上腺素溶液pH值低且具有降低氧气的特性，但在组织中会迅速发生缓冲作用。因此，使用市售利多卡因 - 肾上腺素溶液进行局部浸润似乎与使用新配制的利多卡因 - 肾上腺素溶液一样安全。
