Korey M, Gieser D, Kass M A, Waltman S R, Gordon M, Becker B
Am J Ophthalmol. 1982 Nov;94(5):610-6. doi: 10.1016/0002-9394(82)90005-8.
In order to assess the effect of increased intraocular pressure on the corneal endothelium, we classified 254 patients into four groups: Group 1, those with normal intraocular pressures; Group 2, those with untreated ocular hypertension; Group 3, those with treated ocular hypertension; and Group 4, those with primary open-angle glaucoma. One eye of each patient underwent specular microscopy and pachymetry. The eyes in the four groups did not differ significantly as to central corneal endothelial cell density or central corneal thickness. These measurements were not related to sex, race, or intraocular pressure (P greater than .12 in all cases). Increasing age was associated with a decrease in central corneal endothelial cell density (P = .0001), but was not associated with a change in central corneal thickness (P = .22). There was no significant relationship between the use of topical ocular hypotensive medications and central corneal endothelial cell density (P = .38) or central corneal thickness (P = .07) in patients with ocular hypertension or primary open-angle glaucoma. Neither uncomplicated peripheral iridectomy nor trabeculectomy produced significant changes when preoperative measurements were compared to measurements made 12 weeks postoperatively (P greater than .30 in all cases). Two eyes with flat anterior chambers following trabeculectomy had substantial decreases in central corneal endothelial cell density.
为了评估眼压升高对角膜内皮的影响，我们将254例患者分为四组：第1组，眼压正常者；第2组，未经治疗的高眼压症患者；第3组，已治疗的高眼压症患者；第4组，原发性开角型青光眼患者。每位患者的一只眼睛接受了角膜内皮镜检查和角膜厚度测量。四组患者的中央角膜内皮细胞密度或中央角膜厚度无显著差异。这些测量结果与性别、种族或眼压无关（所有情况下P均大于0.12）。年龄增长与中央角膜内皮细胞密度降低相关（P = 0.0001），但与中央角膜厚度变化无关（P = 0.22）。在高眼压症或原发性开角型青光眼患者中，局部使用降眼压药物与中央角膜内皮细胞密度（P = 0.38）或中央角膜厚度（P = 0.07）之间无显著关系。将术前测量值与术后12周的测量值进行比较时，单纯性周边虹膜切除术和小梁切除术均未产生显著变化（所有情况下P均大于0.30）。小梁切除术后前房扁平的两只眼睛的中央角膜内皮细胞密度大幅下降。
