Wolfs R C, Klaver C C, Vingerling J R, Grobbee D E, Hofman A, de Jong P T
Department of Ophthalmology, Erasmus University Medical School, Rotterdam, The Netherlands.
Am J Ophthalmol. 1997 Jun;123(6):767-72. doi: 10.1016/s0002-9394(14)71125-0.
To perform a cross-sectional study on the distribution of central corneal thickness and its association with intraocular pressure in an elderly population.
We measured central corneal thickness and intraocular pressure in 395 subjects (352 control subjects, 13 patients with ocular hypertension, and 30 patients with primary open-angle glaucoma) aged 55 years or more.
Mean central corneal thickness in the 352 control subjects was 537.4 microm (95% confidence interval [CI], 533.8 to 540.9 microm; range, 427 to 620 microm), with a maximal difference between eyes of 42 microm. There were no differences between sexes and no significant association with age. Linear regression analysis showed an increase of 0.19 mm Hg in intraocular pressure with each 10-microm increase in central corneal thickness (95% CI, 0.09 to 0.28 mm Hg). This association was similar in both eyes and in both sexes. The 13 patients with ocular hypertension had corneas a mean of 16.0 microm thicker (95% CI, -2.6 to +34.6 microm) compared with control subjects (P = .093); the 30 patients with primary open-angle glaucoma had corneas a mean of 21.5 microm thinner (95% CI, 8.8 to 34.1 microm) compared with control subjects (P = .001).
Mean central corneal thickness was similar to that found in clinical studies, was slightly higher in patients with ocular hypertension, and was significantly lower in patients with primary open-angle glaucoma. Intraocular pressure was positively related with central corneal thickness. Central corneal thickness may influence the division between normal and increased intraocular pressure at a simple cutoff point of 21 mm Hg.
对老年人群中央角膜厚度的分布及其与眼压的关系进行横断面研究。
我们测量了395名年龄在55岁及以上受试者（352名对照者、13名高眼压症患者和30名原发性开角型青光眼患者）的中央角膜厚度和眼压。
352名对照者的平均中央角膜厚度为537.4微米（95%置信区间[CI]，533.8至540.9微米；范围，427至620微米），双眼最大差值为42微米。性别之间无差异且与年龄无显著关联。线性回归分析显示，中央角膜厚度每增加10微米，眼压升高0.19毫米汞柱（95%CI，0.09至0.28毫米汞柱）。这种关联在双眼和两性中相似。13名高眼压症患者的角膜比对照者平均厚16.0微米（95%CI，-2.6至+34.6微米）（P = 0.093）；30名原发性开角型青光眼患者的角膜比对照者平均薄21.5微米（95%CI，8.8至34.1微米）（P = 0.001）。
平均中央角膜厚度与临床研究结果相似，高眼压症患者略高，原发性开角型青光眼患者显著较低。眼压与中央角膜厚度呈正相关。中央角膜厚度可能会影响在21毫米汞柱这一简单临界值时正常眼压与眼压升高之间的划分。
