Pilonchery G, Finck C, Minaire P, Messy P, Revol A
Ann Biol Clin (Paris). 1982;40(4):315-9.
Eighteen paraplegics with or without neurogenic osteo-arthropathy (POAN) were evaluated for variations in their urinary excretion levels of total (T), and free (L) hydroxyproline and its non-dialysable (ND) and dialysable (D) peptide fractions. Increases in urinary hydroxyproline, moderate rises in free hydroxyproline and more substantial increases in dialysable and non-dialysable peptide fractions could be observed in these patients who all were affected with osteoporosis of disuse. Only variations in dialysable hydroxyproline could be used to differentiate between POAN + and POAN - patients. Of the various ratios which were analyzed (ND/T, L/ND, and D/ND), the D/ND ratio appears to be the most useful for diagnosis and monitoring of patients with POAN.
对18例伴有或不伴有神经源性骨关节炎（POAN）的截瘫患者，评估其尿中总（T）、游离（L）羟脯氨酸及其非透析（ND）和透析（D）肽组分排泄水平的变化。在这些均患有废用性骨质疏松症的患者中，可观察到尿羟脯氨酸增加、游离羟脯氨酸中度升高以及透析和非透析肽组分更显著增加。只有透析性羟脯氨酸的变化可用于区分POAN阳性和POAN阴性患者。在分析的各种比率（ND/T、L/ND和D/ND）中，D/ND比率似乎对POAN患者的诊断和监测最有用。
