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大鼠尿液中可透析和不可透析的羟脯氨酸：与年龄相关的变化及昼夜变化

Dialysable and non-dialysable hydroxyproline in the rat's urine: age related and diurnal variations.

作者信息

Gaggi R, Gianni A M, Montanaro N

出版信息

J Physiol. 1982 May;326:11-9. doi: 10.1113/jphysiol.1982.sp014173.

DOI:10.1113/jphysiol.1982.sp014173
PMID:7202048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1251455/
Abstract
  1. Urinary dialysable and non-dialysable hydroxyproline, which are considered good indices of bone resorption and neoformation respectively, were determined in rats under conditions that modify skeleton metabolism, such as body growth and parathyroid or calcitonin administration. It was also investigated whether dialysable and non-dialysable hydroxyproline excretions showed significant circadian fluctuations in rats of different ages.2. Dialysable hydroxyproline excretion sharply decreased from the first to the fifth months of age and underwent further gradual reduction up to the fourteenth month of life. Non-dialysable hydroxyproline excretion followed a smoother decrease up to the fifth month, then remained constant. Urinary excretion of non-dialysable hydroxyproline expressed as a percentage of the total hydroxyprolinuria (n.d.%) slowly increased with advancing rat age.3. In 2-, 4- and 6-month old rats, dialysable hydroxyproline excretion showed significant circadian fluctuations with minima and maxima at the end of the dark and light fraction of the cycle respectively. Daily fluctuations were greater in young and adult rats (50-65% of the respective average levels) than in 4-month old rats (25%). Non-dialysable hydroxyproline excretion followed similar but less pronounced patterns. Significant circadian fluctuations of n.d.% were detectable only in 2- and 4-month old rats, with peaks at 04.00-05.00 hr, thus indicating that the bone formation/resorption ratio increased in the nocturnal fraction of the cycle.4. Young rats administered with calcitonin exhibited reduced levels of urinary dialysable but not of non-dialysable hydroxyproline when the hormone was given at 13.30 hr. No changes were observed when calcitonin was injected at 19.30 hr. On the contrary, both diurnal and nocturnal parathyroid hormone administration to young rats caused increased levels of dialysable and non-dialysable hydroxyproline of the same magnitude.
摘要

  1. 在改变骨骼代谢的条件下，如身体生长以及给予甲状旁腺素或降钙素时，测定了大鼠尿液中可透析和不可透析的羟脯氨酸，它们分别被认为是骨吸收和新骨形成的良好指标。还研究了不同年龄大鼠中可透析和不可透析羟脯氨酸的排泄是否呈现明显的昼夜波动。

  2. 可透析羟脯氨酸排泄量从出生后第1个月到第5个月急剧下降，直至第14个月生命期进一步逐渐减少。不可透析羟脯氨酸排泄量在第5个月前下降较为平缓，之后保持稳定。以总羟脯氨酸尿症的百分比表示的不可透析羟脯氨酸尿排泄量随大鼠年龄增长而缓慢增加。

  3. 在2个月、4个月和6个月大的大鼠中，可透析羟脯氨酸排泄呈现明显的昼夜波动，分别在昼夜周期的黑暗期结束和光照期结束时出现最小值和最大值。年轻和成年大鼠（分别为各自平均水平的50 - 65%）的每日波动大于4个月大的大鼠（25%）。不可透析羟脯氨酸排泄呈现类似但不太明显的模式。仅在2个月和4个月大的大鼠中可检测到不可透析羟脯氨酸百分比的明显昼夜波动，峰值出现在04:00 - 05:00时，这表明在昼夜周期的夜间部分骨形成/骨吸收比值增加。

  4. 当在13:30给予降钙素时，给予降钙素的幼鼠尿液中可透析羟脯氨酸水平降低，但不可透析羟脯氨酸水平未降低。当在19:30注射降钙素时未观察到变化。相反，对幼鼠昼夜给予甲状旁腺激素均导致可透析和不可透析羟脯氨酸水平同等程度升高。

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J Physiol. 1982 May;326:11-9. doi: 10.1113/jphysiol.1982.sp014173.
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Nihon Naibunpi Gakkai Zasshi. 1983 Jul 20;59(7):949-61. doi: 10.1507/endocrine1927.59.7_949.
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Effect of bioflavonoids on the urinary excretion of hydroxyproline, hydroxylysyl glycosides and hexosamine in adjuvant arthritis.生物类黄酮对佐剂性关节炎中羟脯氨酸、羟赖氨酰糖苷和氨基己糖尿排泄的影响。
Ital J Biochem. 1980 Mar-Apr;29(2):89-101.

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本文引用的文献

1
Modifications of a specific assay for hydroxyproline in urine.尿中羟脯氨酸特定检测方法的改进。
Anal Biochem. 1967 May;19(2):249-55. doi: 10.1016/0003-2697(67)90160-1.
2
Diurnal variation of plasma calcium and calcitonin function in the rat.大鼠血浆钙和降钙素功能的昼夜变化
J Physiol. 1972 May;222(3):559-67. doi: 10.1113/jphysiol.1972.sp009814.
3
Nondialyzable urinary hydroxyproline as an index of bone collagen formation.非透析性尿羟脯氨酸作为骨胶原形成的指标。
J Clin Endocrinol Metab. 1970 Mar;30(3):282-7. doi: 10.1210/jcem-30-3-282.
4
Biochemistry of the hydroxyprolines.羟脯氨酸的生物化学
Adv Enzymol Relat Areas Mol Biol. 1973;37:273-347. doi: 10.1002/9780470122822.ch5.
5
Urinary polypeptides related to collagen synthesis.与胶原蛋白合成相关的尿多肽。
J Clin Invest. 1970 Apr;49(4):716-29. doi: 10.1172/JCI106284.
6
Relationship of blood concentrations of calcium, phosphate, gastrin and calcitonin to the onset of feeding in the rat.大鼠血液中钙、磷、胃泌素和降钙素浓度与进食开始的关系。
Proc Soc Exp Biol Med. 1975 Sep;149(4):855-9. doi: 10.3181/00379727-149-38913.
7
Evaluation of a new technique for measuring bone formation.一种测量骨形成的新技术的评估。
Med Lab Technol. 1975 Apr;32(2):91-8.
8
Daily fluctuations in plasma calcium, phosphate, and their radionuclide concentrations in the rat.大鼠血浆钙、磷及其放射性核素浓度的每日波动情况。
Calcif Tissue Res. 1975;17(2):91-102. doi: 10.1007/BF02547282.
9
Patterns of urinary calcium and phosphate excretion in restrained rats.束缚大鼠尿钙和磷排泄模式
Calcif Tissue Res. 1977 May;22 Suppl:463-5. doi: 10.1007/BF02064131.
10
[Circadian variations in rat serum and urinary calcium and phosphorus. Reflections on the Ca/PO4 ratio].[大鼠血清及尿中钙和磷的昼夜变化。对钙/磷比值的思考]
Arch Sci Biol (Bologna). 1978 Jan-Dec;62(1-4):1-11.