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EFFECTS OF HORMONES UPON ADIPOSE TISSUE MEMBRANE ELECTRICAL POTENTIALS.激素对脂肪组织膜电位的影响。
Proc Soc Exp Biol Med. 1964 May;116:31-5. doi: 10.3181/00379727-116-29149.
2
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.分离脂肪细胞的代谢。I. 激素对葡萄糖代谢和脂肪分解的影响。
J Biol Chem. 1964 Feb;239:375-80.
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Effect of insulin and rat weight upon rat adipose tissue membrane resting electrical potential (REP).胰岛素和大鼠体重对大鼠脂肪组织膜静息电位（REP）的影响。
Diabetes. 1963 May-Jun;12:262-7. doi: 10.2337/diab.12.3.262.
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A rapid enzymatic assay for glycerol.一种用于甘油的快速酶促测定法。
Nature. 1962 Dec 8;196:987-8. doi: 10.1038/196987a0.
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Effect of insulin upon resting electrical potential of adipose tissue.胰岛素对脂肪组织静息电位的影响。
Proc Soc Exp Biol Med. 1962 Jul;110:590-5. doi: 10.3181/00379727-110-27588.
6
Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ.完整突触体中的能量转导。质膜去极化对原位测定的线粒体内呼吸和膜电位的影响。
Biochem J. 1980 Jan 15;186(1):21-33. doi: 10.1042/bj1860021.
7
Determination of the mitochondrial protonmotive force in isolated hepatocytes.分离的肝细胞中线粒体质子动力的测定。
J Biol Chem. 1980 Feb 25;255(4):1458-64.
8
Effects of ionophores and metabolic inhibitors on the mitochondrial membrane potential within isolated hepatocytes as measured with the safranine method.用番红法测定离子载体和代谢抑制剂对分离的肝细胞线粒体内膜电位的影响。
Biochem J. 1980 Oct 15;192(1):183-90. doi: 10.1042/bj1920183.
9
The effect of insulin on plasma-membrane and mitochondrial-membrane potentials in isolated fat-cells.胰岛素对分离脂肪细胞的质膜电位和线粒体膜电位的影响。
Biochem J. 1981 Apr 15;196(1):133-47. doi: 10.1042/bj1960133.
10
Effects of insulin, catecholamines, and cyclic nucleotides on rat adipocyte membrane potential.胰岛素、儿茶酚胺和环核苷酸对大鼠脂肪细胞膜电位的影响。
J Biol Chem. 1981 Jan 25;256(2):649-55.

β-肾上腺素能激动剂对原位脂肪细胞线粒体膜电位的影响。

The effect of beta-adrenergic agonists on the membrane potential of fat-cell mitochondria in situ.

作者信息

Davis R J, Martin B R

出版信息

Biochem J. 1982 Sep 15;206(3):611-8. doi: 10.1042/bj2060611.

DOI:10.1042/bj2060611
PMID:7150265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1158630/
Abstract
  1. The accumulation of [3H]methyltriphenylphosphonium by isolated fat-cells was used to estimate the membrane potential of mitochondria in situ. 2. Adrenaline caused a large decrease in the accumulation of [3H]methyltriphenylphosphonium. Mitochondria in fat-cells incubated in the presence of adrenaline had a very low calculated membrane potential. This effect was also given by isoprenaline (a beta-adrenergic agonist) and was blocked by propranolol (a beta-adrenergic antagonist). 3. The effect of isoprenaline could be partially antagonized by the use of media with high albumin concentrations. Addition of sodium oleate to saturate the fatty acid-binding sites on the albumin reversed this antagonism. 4. It is proposed that the decrease in the calculated mitochondrial membrane potential is due to the uncoupling effect of the non-esterified fatty acids released by the stimulation of lipolysis observed in the presence of beta-adrenergic agonists.
摘要
  1. 利用分离的脂肪细胞对[³H]甲基三苯基鏻的摄取来估计原位线粒体的膜电位。2. 肾上腺素导致[³H]甲基三苯基鏻的摄取大幅减少。在肾上腺素存在下孵育的脂肪细胞中的线粒体计算出的膜电位非常低。异丙肾上腺素（一种β-肾上腺素能激动剂）也有此作用，且被普萘洛尔（一种β-肾上腺素能拮抗剂）阻断。3. 高白蛋白浓度的培养基可部分拮抗异丙肾上腺素的作用。添加油酸钠使白蛋白上的脂肪酸结合位点饱和可逆转这种拮抗作用。4. 有人提出，计算出的线粒体膜电位降低是由于在β-肾上腺素能激动剂存在下观察到的脂解刺激释放的非酯化脂肪酸的解偶联作用。