小鼠对伤寒沙门氏菌感染的先天抵抗力。
Innate resistance of mice to Salmonella typhi infection.
作者信息
O'Brien A D
出版信息
Infect Immun. 1982 Dec;38(3):948-52. doi: 10.1128/iai.38.3.948-952.1982.
Abstract
The basis for the natural resistance of mice to Salmonella typhi was examined. In contrast to Salmonella typhimurium, the virulence of S. typhi for mice was independent of the mouse strain and was not affected by inactivation of murine macrophages with silica. However, mice were more susceptible to S. typhi when given iron alone or iron and an iron chelator. The results suggest that the failure of S. typhi to undergo net growth in murine tissues reflects an inability of the bacterium to multiply rather than rapid killing by resident macrophages.
摘要
对小鼠对伤寒沙门氏菌天然抵抗力的基础进行了研究。与鼠伤寒沙门氏菌不同，伤寒沙门氏菌对小鼠的毒力与小鼠品系无关，并且不受用二氧化硅使小鼠巨噬细胞失活的影响。然而，单独给予铁或铁与铁螯合剂时，小鼠对伤寒沙门氏菌更易感。结果表明，伤寒沙门氏菌在小鼠组织中未能实现净生长反映了该细菌无法繁殖，而非被驻留巨噬细胞快速杀灭。
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本文引用的文献
1
STUDIES ON THE INFLUENCE OF THE ROUTE OF IMMUNIZATION IN THE ACTIVE MOUSE PROTECTION TEST WITH INTRAPERITONEAL CHALLENGE FOR POTENCY ASSAY OF TYPHOID VACCINES.
Bull World Health Organ. 1964;31(6):793-8.
2
Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci.
Nature. 1980 Oct 2;287(5781):440-2. doi: 10.1038/287440a0.
3
Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.
J Immunol. 1980 Jan;124(1):20-4.
4
The effect of adding iron to mucin on the enhancement of virulence for mice of Salmonella typhi strain TY 2.
J Biol Stand. 1980;8(1):79-85. doi: 10.1016/s0092-1157(80)80049-7.
5
Host-parasite relations in mouse typhoid.
J Exp Med. 1966 Oct 1;124(4):573-83. doi: 10.1084/jem.124.4.573.
6
Salmonella enteritis. II. Fulminant diarrhea in and effects on the small intestine.
Am J Dig Dis. 1971 Nov;16(11):1007-13. doi: 10.1007/BF02235013.
7
Typhoid fever: pathogenesis and immunologic control.
N Engl J Med. 1970 Sep 24;283(13):686-91. doi: 10.1056/NEJM197009242831306.
8
Salmonellosis in orally infected specific pathogen-free C57B1 mice.
Infect Immun. 1972 Feb;5(2):191-8. doi: 10.1128/iai.5.2.191-198.1972.
9
Growth of typhoid and paratyphoid bacilli in intravenously infected mice.
Infect Immun. 1974 Oct;10(4):816-22. doi: 10.1128/iai.10.4.816-822.1974.
10
Genetics of resistance to infection with Salmonella typhimurium in mice.
J Infect Dis. 1976 Jan;133(1):72-8. doi: 10.1093/infdis/133.1.72.
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