O'Brien A D
Infect Immun. 1982 Dec;38(3):948-52. doi: 10.1128/iai.38.3.948-952.1982.
The basis for the natural resistance of mice to Salmonella typhi was examined. In contrast to Salmonella typhimurium, the virulence of S. typhi for mice was independent of the mouse strain and was not affected by inactivation of murine macrophages with silica. However, mice were more susceptible to S. typhi when given iron alone or iron and an iron chelator. The results suggest that the failure of S. typhi to undergo net growth in murine tissues reflects an inability of the bacterium to multiply rather than rapid killing by resident macrophages.
对小鼠对伤寒沙门氏菌天然抵抗力的基础进行了研究。与鼠伤寒沙门氏菌不同，伤寒沙门氏菌对小鼠的毒力与小鼠品系无关，并且不受用二氧化硅使小鼠巨噬细胞失活的影响。然而，单独给予铁或铁与铁螯合剂时，小鼠对伤寒沙门氏菌更易感。结果表明，伤寒沙门氏菌在小鼠组织中未能实现净生长反映了该细菌无法繁殖，而非被驻留巨噬细胞快速杀灭。
