Collins F M
Infect Immun. 1972 Feb;5(2):191-8. doi: 10.1128/iai.5.2.191-198.1972.
Specific pathogen-free C57B1 mice are 100 to 1,000 times as sensitive as CD-1 mice to intravenous or oral challenge by Salmonella enteritidis or S. gallinarum. Resistance to infection by S. pullorum was unaffected. Growth of Listeria monocytogenes and Mycobacterium bovis (BCG) in intravenously infected C57B1 mice was similar to that seen in CD-1 mice. Quantitative counts of viable S. enteritidis in the walls of the stomach, small intestine, cecum, and large intestine and in the corresponding intestinal contents showed that most of the oral challenge inoculum was rapidly inactivated so that, by 24 hr, less than 1% was still viable. Overnight starvation and pretreatment with bicarbonate solution increased the relative survival of the challenge approximately 10-fold. Despite the rapid and extensive inactivation of the oral inoculum within the normal intestine, significant numbers of salmonellae reached the liver and spleen by 48 hr, and this systemic infection was subsequently responsible for the death of a high proportion of the challenged animals.
无特定病原体的C57B1小鼠对肠炎沙门氏菌或鸡沙门氏菌静脉内或口服攻击的敏感性比CD-1小鼠高100至1000倍。对鸡白痢沙门氏菌感染的抵抗力不受影响。单核细胞增生李斯特菌和牛分枝杆菌（卡介苗）在静脉感染的C57B1小鼠中的生长情况与在CD-1小鼠中相似。对胃、小肠、盲肠和大肠壁以及相应肠内容物中肠炎沙门氏菌活菌的定量计数表明，大部分口服攻击接种物迅速失活，以至于到24小时时，仍存活的不到1%。过夜禁食和用碳酸氢盐溶液预处理可使攻击接种物的相对存活率提高约10倍。尽管正常肠道内口服接种物迅速且广泛地失活，但到48小时时仍有大量沙门氏菌到达肝脏和脾脏，这种全身感染随后导致很大比例的受攻击动物死亡。
