Schwartz R H, Rodriguez W J
Pediatr Infect Dis. 1982 Sep-Oct;1(5):333-5. doi: 10.1097/00006454-198209000-00010.
Persistent otitis media with effusion (POME) is found in 50% of young children after 10 days of antimicrobial therapy for acute otitis media. Pathogenic bacteria are present in at least 25% of such effusions. We studied the effect of a 2-week course of trimethoprim-sulfamethoxazole (TMP-SMX) administered to 33 children who had POME and compared the results obtained to those of a similar group of children with POME who did not receive drug therapy. This study was designed to answer two questions: (1) Would TMP-SMX promote the resolution of POME? (2) Would TMP-SMX prevent an attack of acute otitis media (AOM) superimposed on POME? The diagnosis of POME was validated by obtaining a type B tympanogram, and AOM was diagnosed according to strict criteria. Each child was randomly assigned either to a treatment group that received a 14-day course of TMP-SMX or to a control group that received no medication. TMP-SMX failed to promote resolution of POME but did prevent recurrent AOM. During the second 2-week (follow-up) phase of the study, when no antimicrobial was given to either subject group, the incidence of AOM was similar in both groups.
在对急性中耳炎进行抗菌治疗10天后，50%的幼儿会出现持续性中耳积液（POME）。至少25%的此类积液中存在病原菌。我们对33例患有POME的儿童进行了为期2周的甲氧苄啶-磺胺甲恶唑（TMP-SMX）疗程研究，并将结果与另一组未接受药物治疗的类似POME儿童组进行比较。本研究旨在回答两个问题：（1）TMP-SMX是否会促进POME的消退？（2）TMP-SMX是否会预防叠加在POME上的急性中耳炎（AOM）发作？通过获得B型鼓室图来验证POME的诊断，AOM则根据严格标准进行诊断。每个儿童被随机分配到接受14天TMP-SMX疗程的治疗组或不接受药物治疗的对照组。TMP-SMX未能促进POME的消退，但确实预防了复发性AOM。在研究的第二个2周（随访）阶段，当两个受试组均未给予抗菌药物时，两组中AOM的发生率相似。
