Hertzer N R, Loop F D, Taylor P C, Beven E G
Surgery. 1978 Dec;84(6):803-11.
Between 1969 and 1976, 174 patients were treated surgically for simultaneous carotid and coronary atherosclerosis. In 59 patients, staged carotid endarterectomy was performed a few days to 6 months prior to myocardial revascularization. Severe (more than 60% stenosis) coronary atherosclerosis affected a single vessel in 11 patients (19%), two vessels in 20 patients (34%), and three vessels in 28 patients (47%). Left ventricular contraction was impaired in 30 patients (51%). Nine patients (15%) had previous neurological symptoms, and 50 patients (85%) had asymptomatic carotid stenosis. One patient (1.5%) had a permanent stroke after carotid endarterectomy. There were no permanent strokes after staged myocardial revascularization, and the early mortality rate was 1.7%. Combined carotid endarterectomy and myocardial revascularization were performed in 115 patients with severe cardiac disease. Coronary atherosclerosis affected a single vessel in 10 patients (9%), two vessels in 39 patients (34%), and three vessels in 66 patients (57%). Left ventricular impairment was present in 72 patients (63%). Thirty-five patients (30%) had previous neurological symptoms, and 80 patients (70%) had asymptomatic carotid stenosis. Five patients (4.3%) had permanent strokes after combined revascularization, and four of these patients had occlusion or severe stenosis of the contralateral internal carotid artery. The early mortality rate was 4.3%, but no deaths could be attributed to carotid repair. The results suggest that significant simultaneous carotid and coronary atherosclerosis should be corrected in selected patients by staged operations when feasible. In the presence of severe cardiac disease, a combined precedure may be performed in face of higher risk of intraoperative stroke.
1969年至1976年间,174例患者因同时患有颈动脉和冠状动脉粥样硬化而接受了外科治疗。59例患者在心肌血运重建术前几天至6个月进行了分期颈动脉内膜切除术。严重(狭窄超过60%)冠状动脉粥样硬化累及单支血管的有11例患者(19%),累及两支血管的有20例患者(34%),累及三支血管的有28例患者(47%)。30例患者(51%)左心室收缩功能受损。9例患者(15%)既往有神经症状,50例患者(85%)有无症状性颈动脉狭窄。1例患者(1.5%)在颈动脉内膜切除术后发生永久性卒中。分期心肌血运重建术后无永久性卒中发生,早期死亡率为1.7%。115例患有严重心脏病的患者接受了颈动脉内膜切除术和心肌血运重建联合手术。冠状动脉粥样硬化累及单支血管的有10例患者(9%),累及两支血管的有39例患者(34%),累及三支血管的有66例患者(57%)。72例患者(63%)存在左心室功能损害。35例患者(30%)既往有神经症状,80例患者(70%)有无症状性颈动脉狭窄。5例患者(4.3%)在联合血运重建术后发生永久性卒中,其中4例患者对侧颈内动脉闭塞或严重狭窄。早期死亡率为4.3%,但无死亡可归因于颈动脉修复。结果表明,在可行的情况下,对于选定的患者,应通过分期手术纠正同时存在的严重颈动脉和冠状动脉粥样硬化。在存在严重心脏病的情况下,面对术中卒中风险较高的情况,可进行联合手术。