Vernersson E, Ahlgren I, Aronsen K F, Palmer B
Acta Chir Scand. 1983;149(1):15-22.
The hemodynamics were monitored during 24 hours in piglets anesthetized with Pentothal-N2O/O2, submitted to 33% full-thickness skin burn and resuscitated with 2.4 ml/kg/% burn of 100 mmol NaCl in 2.5% glucose. Three groups were studied: (I) standardized burn, (II) standardized burn and excision after 5 hours, (III) standardized burn, excision and lysine-vasopressin (LVP) given as intravenous infusion in a vasopressor dose. All groups showed similar decrease of cardiac output (CO), which was about 30% 4 hours after burn. In the two groups with burn excision, however, CO recovery was earlier than in the conservatively treated group I. The improvement was significant between group III and group I. LVP led to higher CO fraction and greater blood flow to hepatic artery, reduced flow to proximal gastrointestinal tract and skin and unchanged flow to heart, kidneys and other organs 24 hours after burn. The mean blood loss during and after burn excision was greatly reduced in group III (50 g/25 kg) compared with group II (146 g/25 kg). The therapeutic implications of LVP in excisional burn treatment are discussed.
对用硫喷妥钠 - N₂O/O₂麻醉的仔猪进行24小时血流动力学监测，使其遭受33%的全层皮肤烧伤，并用每千克体重每百分比烧伤面积2.4毫升的100毫摩尔氯化钠溶于2.5%葡萄糖溶液进行复苏。研究了三组：（I）标准烧伤组，（II）标准烧伤并在5小时后切除烧伤组织组，（III）标准烧伤、切除烧伤组织并以升压剂量静脉输注赖氨酸加压素（LVP）组。所有组的心输出量（CO）均出现类似下降，烧伤后4小时约下降30%。然而，在两组进行烧伤组织切除的组中，心输出量的恢复早于保守治疗的I组。III组和I组之间的改善具有显著性。LVP使烧伤后24小时的心输出量分数更高，肝动脉血流量增加，近端胃肠道和皮肤的血流量减少，心脏、肾脏和其他器官的血流量不变。与II组（146克/25千克）相比，III组在烧伤组织切除期间及之后的平均失血量大幅减少（50克/25千克）。讨论了LVP在切除性烧伤治疗中的治疗意义。
