Vernersson E, Aronsen K F, Aberg M
Eur Surg Res. 1985;17(4):242-50. doi: 10.1159/000128473.
The circulatory and renal effects of a deep dermal burn, covering one third of the total body surface area were studied in 12 thiopentone/N2O anesthetized piglets. Central circulation and renal function was monitored during 24 h and regional blood flows were determined before burn, 5 and 24 h after burn using radioactively labeled microspheres. One group was treated conservatively with fluid infusion only (control group) and the other with fluids, intermittent injections of a long-acting hormonogen, triglycyl-lysine-vasopressin (TGLVP), and excision 5 h after burn. There was earlier circulatory recovery in the TGLVP excision group with significantly higher arterial blood pressure and cardiac output than in the controls. TGLVP induced a major redistribution of blood flows, favoring the liver at the expense of the gastrointestinal tract, carcass and skin, while the blood flows were unchanged to the brain, heart and kidneys. There were also increased excretions of sodium and potassium and a temporarily increased diuresis. The earlier circulatory stabilization and blood flow redistribution might have clinical implications in burn care.
对12只硫喷妥钠/氧化亚氮麻醉的仔猪进行了研究，观察了占全身表面积三分之一的深度皮肤烧伤对循环系统和肾脏的影响。在24小时内监测中心循环和肾功能，并在烧伤前、烧伤后5小时和24小时使用放射性标记微球测定局部血流。一组仅通过液体输注进行保守治疗（对照组），另一组则进行液体治疗、间歇性注射长效激素原三甘氨酰赖氨酸加压素（TGLVP）并在烧伤后5小时进行切除。TGLVP切除组的循环恢复较早，动脉血压和心输出量明显高于对照组。TGLVP引起血流的主要重新分布，使肝脏血流增加，而胃肠道、胴体和皮肤的血流减少，而脑、心脏和肾脏的血流不变。钠和钾的排泄也增加，尿量暂时增加。早期的循环稳定和血流重新分布可能对烧伤护理具有临床意义。
