Vernersson E, Jacobsson S, Aberg M
Scand J Plast Reconstr Surg. 1984;18(3):291-6. doi: 10.3109/02844318409052853.
In a burn model using anesthetized piglets, the circulatory and renal effects and the blood loss during and after excision were compared in two groups, one treated by triglycyl-lysine-vasopressin (TGLVP) given as intermittent bolus injections and the other serving as control. The third degree burn covered approximately 33% of the body surface area, and a solution containing 100 mmol NaCl/l in 2.5% glucose was infused at a rate of 2.4 ml/kg/% burn. Regional blood flows were determined before burn, 5 and 24 h after burn with the aid of radioactively labeled microspheres. Cardiac output (CO) decreased about 30% after burn and there was a slight further decrease of CO after the first TGLVP dose. After the excision there were similar restitutions of CO in the two groups. TGLVP induced an increase of blood flow to the hepatic artery, did not change flows to the brain, heart and kidneys and decreased flows to the preportal organs, carcass and skin 5 h after burn. After 24 h the perfusion of the skin and pancreas remained low but there were no differences in other organs. There was a significant decrease of blood loss associated with burn excision performed 5 h after burn in the TGLVP treated group, mean blood loss 39 g/25 kg versus 145 g/25 kg in the control group. There was a temporary increase in diuresis following TGLVP and also increased excretions of sodium and potassium. The results obtained in this study and possible clinical applications are discussed.
在一个使用麻醉仔猪的烧伤模型中，比较了两组在切除过程中和切除后循环系统和肾脏的影响以及失血量，一组通过间歇性推注给予三甘氨酰赖氨酸加压素（TGLVP）进行治疗，另一组作为对照组。三度烧伤覆盖了大约33%的体表面积，以2.4 ml/kg/%烧伤的速率输注含100 mmol NaCl/l于2.5%葡萄糖中的溶液。借助放射性标记微球在烧伤前、烧伤后5小时和24小时测定局部血流量。烧伤后心输出量（CO）下降约30%，首次给予TGLVP剂量后CO略有进一步下降。切除后两组的CO恢复情况相似。TGLVP使肝动脉血流量增加，不改变脑、心脏和肾脏的血流量，并在烧伤后5小时使门静脉前器官、胴体和皮肤的血流量减少。24小时后，皮肤和胰腺的灌注仍然较低，但其他器官没有差异。在TGLVP治疗组中，烧伤后5小时进行烧伤切除相关的失血量显著减少，平均失血量为39 g/25 kg，而对照组为145 g/25 kg。TGLVP后出现短暂的利尿增加，钠和钾的排泄也增加。讨论了本研究获得的结果及其可能的临床应用。
