Andrén-Sandberg A, Dawiskiba S, Ihse I
Acta Chir Scand. 1982;148(6):511-5.
Hamsters were subjected to cholecysto-duodenostomy and a small suprapancreatic bile-duct resection in order to preclude bile reflux into the pancreatic ducts. The model was used to investigate the role of bile reflux in the pancreatic carcinogenic action of BHP (N-nitrosobis(2-hydroxypropyl)amine). The carcinogen was given by weekly injection for 20 or 24 weeks. No statistically significant effects of the bile deviation on tumour frequency were found at the end of either time. BHP per se did not induce tumours in any preferential area of the gland. The tumours thus were uniformly distributed. Corresponding distribution was found in the hamsters with choledochoduodenostomy. The histologic appearance of the pancreatic lesions was the same in hamsters with and without choledochoduodenostomy. The findings do not support the concept of bile reflux as an aetiologic factor in experimental pancreatic carcinogenesis.
仓鼠接受了胆囊十二指肠吻合术和胰上胆管小部分切除术，以防止胆汁反流至胰管。该模型用于研究胆汁反流在BHP（N-亚硝基双（2-羟丙基）胺）诱发胰腺癌作用中的角色。致癌物通过每周注射给药，持续20或24周。在两个时间段结束时，均未发现胆汁改道对肿瘤发生率有统计学上的显著影响。BHP本身并未在胰腺的任何特定区域诱发肿瘤。因此，肿瘤分布均匀。在接受胆总管十二指肠吻合术的仓鼠中也发现了相应的分布情况。有无胆总管十二指肠吻合术的仓鼠胰腺病变的组织学表现相同。这些发现不支持胆汁反流是实验性胰腺癌发生病因学因素的观点。
