Pour P, Donnelly T
Cancer Res. 1978 Jul;38(7):2048-51.
The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution to those of animals in other studies without surgery. Hence the findings contraindicate the importance of biliary reflux in pancreatic tumor induction. Other possible mechanisms are discussed.
在对叙利亚金黄地鼠进行胆囊十二指肠吻合术和胆总管吻合术后，给予其胰腺致癌物N-亚硝基双（2-氧代丙基）胺，以研究胆汁反流机制作为胰腺致癌因素的可能性。所诱导的病变在形态、数量和分布上与其他未进行手术的研究中的动物相似。因此，这些发现排除了胆汁反流在诱发胰腺肿瘤中的重要性。文中还讨论了其他可能的机制。
