Shiozawa Z, Yamada H, Mabuchi C, Hotta T, Saito M, Sobue I, Huang Y P
Ann Neurol. 1982 Dec;12(6):578-80. doi: 10.1002/ana.410120613.
Of 27 patients with hypoplastic anemia treated between 1971 and 1974 with male hormone and protein-assimilating hormone, 3 developed superior sagittal sinus thrombosis (SSST). The clinical symptoms and signs and angiographic findings of SST were characteristic enough to allow an early diagnosis. Signs related to SST were seizures, hemiplegia, facial palsy, stupor, and coma, with the most important prodrome and consistent subjective complaint being headache. Following discontinuation of the hormone therapy, neurological signs and symptoms related to SSST gradually subsided. In all cases, the hematological picture improved with discontinuation of the hormone therapies. It appears that administration of male hormone can be associated with the development of SSST. If neurological symptoms and signs of SSST appear, administration of the hormones should be discontinued.
在1971年至1974年间接受雄性激素和蛋白质同化激素治疗的27例再生障碍性贫血患者中，有3例发生了上矢状窦血栓形成（SSST）。SSST的临床症状、体征及血管造影表现具有足够的特征性，足以早期诊断。与SSST相关的体征包括癫痫发作、偏瘫、面瘫、昏迷和木僵，最重要的前驱症状及持续存在的主观主诉是头痛。停用激素治疗后，与SSST相关的神经体征和症状逐渐消退。在所有病例中，停用激素治疗后血液学情况均有所改善。看来雄性激素的使用可能与SSST的发生有关。如果出现SSST的神经症状和体征，应停用激素。
