Dai A, Wasay M, Dubey N, Giglio P, Bakshi R
Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA.
J Stroke Cerebrovasc Dis. 2000 Mar-Apr;9(2):89-90. doi: 10.1053/jscd.2000.0090089.
Superior sagittal sinus thrombosis (SSST) is associated with a variety of hypercoaguable states. Although coagulation disturbances are reported in hyperthyroidism, a direct link between hyperthyroidism and cerebral venous thrombosis is not established. We report a 39-year-old man who developed increased intracranial pressure, seizures, and rapid atrial fibrillation. Neuroimaging showed SSST, and laboratory studies were consistent with hyperthyroidism. No other causes of a hypercoaguable state were identified. Prompt treatment of his hyperthyroidism led to recanalization of the superior sagittal sinus and a full neurological recovery. Given the known effects of hyperthyroidism on factor VIII activity, we hypothesize that hyperthyroidism is an independent risk factor for SSST. A high index of suspicion for SSST is warranted in patients with hyperthyroidism and neurological symptoms. Furthermore, thyroid dysfunction should be excluded in patients with unexplained SSST.
上矢状窦血栓形成（SSST）与多种高凝状态相关。尽管有报道称甲状腺功能亢进症存在凝血紊乱，但甲状腺功能亢进症与脑静脉血栓形成之间的直接联系尚未确立。我们报告了一名39岁男性，他出现了颅内压升高、癫痫发作和快速房颤。神经影像学检查显示为SSST，实验室检查结果与甲状腺功能亢进症相符。未发现其他导致高凝状态的原因。对其甲状腺功能亢进症的及时治疗导致上矢状窦再通，神经功能完全恢复。鉴于甲状腺功能亢进症对因子VIII活性的已知影响，我们推测甲状腺功能亢进症是SSST的独立危险因素。对于患有甲状腺功能亢进症和神经症状的患者，有必要高度怀疑SSST。此外，对于原因不明的SSST患者，应排除甲状腺功能障碍。
