Hausen B M
Derm Beruf Umwelt. 1982;30(6):189-92.
A 40-year-old woman developed dermatitis of the left forearm after wearing a bracelet manufactured from Brazilian rosewood (Dalbergia nigra All.). Swelling of the lips, itching and vesicles recurred when she played a recorder made from the same timber some years later. Epicutaneous tests were strongly positive after 120 h with 2 of the wood constituents: R-4-methoxydalbergione and S-4,4'-dimethoxydalbergione. The third quinone (S-4'-hydroxy-4-methoxydalbergione) only elicited a weak reaction. Shavings of the wooden bracelet extracted with benzene and ethanol and separation of the residues by thin layer chromatography yielded all 3 dalbergiones in remarkable amounts (congruent to 0,8%). Cross-reactions to the chemically near related R-3,4-dimethoxydalbergione, known as the strongest sensitiser of the dalbergione group, were not obtained, although guinea pig experiments had revealed cross-reactivities. Of the racemic 4-methoxydalbergione the dextrorotatory form elicited stronger responses than the S-form.
一名40岁女性佩戴由巴西黄檀（Dalbergia nigra All.）制成的手镯后，左前臂出现皮炎。几年后，当她吹奏用同一种木材制成的竖笛时，嘴唇肿胀、瘙痒和水疱复发。皮试在120小时后对两种木材成分呈强阳性反应：R - 4 - 甲氧基黄檀醌和S - 4,4'-二甲氧基黄檀醌。第三种醌（S - 4'-羟基 - 4 - 甲氧基黄檀醌）仅引起微弱反应。用苯和乙醇提取木制手镯的刨花，并通过薄层色谱法分离残留物，得到了所有三种含量可观的黄檀醌（约0.8%）。尽管豚鼠实验显示存在交叉反应，但未观察到与化学性质相近的R - 3,4 - 二甲氧基黄檀醌（已知为黄檀醌类中最强的致敏剂）的交叉反应。在外消旋4 - 甲氧基黄檀醌中，右旋形式比S - 形式引起的反应更强。
