Guilleminault C, Winkle R, Korobkin R, Simmons B
Eur J Pediatr. 1982 Nov;139(3):165-71. doi: 10.1007/BF01377349.
Twenty-five children, age range 2 to 14 years (mean age = 7), were referred to the Stanford University Sleep Disorders Clinic for various clinical symptoms, including excessive daytime somnolence, heavy nocturnal snoring, and abnormal daytime behavior. All children (10 girls and 15 boys) were polygraphically monitored during sleep. No sleep apnea syndrome or oxygen desaturation was revealed. However, each child presented significant respiratory resistive load during sleep associated with electrocardiographic R-R interval and endoesophageal pressure swings. The most laborious breathing occurred during REM sleep. Second degree atrioventricular blocks were also noted. Tonsillectomy and/or adenoidectomy was performed in every case and resulted in a complete disappearance or substantial amelioration of the reported symptoms. Objective evaluation by Multiple Sleep Latency Test and Wilkinson Addition Test confirmed the beneficial effect of surgery.
25名年龄在2至14岁(平均年龄=7岁)的儿童因各种临床症状被转诊至斯坦福大学睡眠障碍诊所,这些症状包括白天过度嗜睡、夜间严重打鼾和异常的白天行为。所有儿童(10名女孩和15名男孩)在睡眠期间均接受了多导睡眠监测。未发现睡眠呼吸暂停综合征或氧饱和度降低。然而,每个儿童在睡眠期间均表现出与心电图R-R间期和食管内压力波动相关的显著呼吸阻力负荷。最费力的呼吸发生在快速眼动睡眠期间。还注意到二度房室传导阻滞。所有病例均进行了扁桃体切除术和/或腺样体切除术,术后报告的症状完全消失或显著改善。通过多次睡眠潜伏期试验和威尔金森加法试验进行的客观评估证实了手术的有益效果。