Ogiso T, Arai Y, Fukushima S, Nishizuka Y, Ito N
Gan. 1982 Dec;73(6):862-9.
The effects of diethylstilbestrol (DES) on the development of urinary bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in neonatally castrated rats and on metaplastic changes of the coagulating glands and ejaculatory ducts were studied. Pretreatment with DES during infancy increased the incidence of preneoplastic lesions, papillomas, and cancers of the urinary bladder in BBN-treated males. Pretreatment with DES was more effective in castrated males than in uncastrated males. BBN did not induce tumors of the coagulating glands or ejaculatory ducts, in which metaplastic changes were observed in DES-treated rats.
研究了己烯雌酚（DES）对新生期去势大鼠中由N-丁基-N-（4-羟基丁基）亚硝胺（BBN）诱导的膀胱癌发生的影响，以及对凝固腺和射精管化生变化的影响。在婴儿期用DES预处理增加了BBN处理的雄性大鼠膀胱的癌前病变、乳头状瘤和癌症的发生率。DES预处理对去势雄性大鼠比未去势雄性大鼠更有效。BBN未诱导凝固腺或射精管肿瘤，但在DES处理的大鼠中观察到了这些部位的化生变化。
