Enhancing effect of diethylstilbestrol on urinary bladder carcinogenesis in neonatally castrated male rats.
作者信息
Ogiso T, Arai Y, Fukushima S, Nishizuka Y, Ito N
出版信息
Gan. 1982 Dec;73(6):862-9.
PMID:7160579
Abstract
The effects of diethylstilbestrol (DES) on the development of urinary bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in neonatally castrated rats and on metaplastic changes of the coagulating glands and ejaculatory ducts were studied. Pretreatment with DES during infancy increased the incidence of preneoplastic lesions, papillomas, and cancers of the urinary bladder in BBN-treated males. Pretreatment with DES was more effective in castrated males than in uncastrated males. BBN did not induce tumors of the coagulating glands or ejaculatory ducts, in which metaplastic changes were observed in DES-treated rats.
摘要
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