Knop J, Riechmann R
Arch Dermatol Res. 1982;274(1-2):155-8. doi: 10.1007/BF00510368.
Local application of alpha-L-fucose on the ear before elicitation of contact allergy to dinitrofluorobenzene (DNFB) in BALB/c mice results in a suppression of the contact allergic response. However, local application of alpha-L-fucose at the sensitization site on the abdominal wall before sensitizing the animals with DNFB had no inhibitory effect on contact allergy. Alpha-L-fucose has been demonstrated to inhibit lymphokine activity in vitro and manifestation of cellular immunity in vivo. Our results suggest that alpha-L-fucose suppresses contact allergy by locally inhibiting the efferent phase of the cellular immune response.
在BALB/c小鼠对二硝基氟苯（DNFB）产生接触性过敏之前，在耳部局部应用α-L-岩藻糖会导致接触性过敏反应受到抑制。然而，在用DNFB致敏动物之前，在腹壁致敏部位局部应用α-L-岩藻糖对接触性过敏没有抑制作用。α-L-岩藻糖已被证明在体外可抑制淋巴因子活性，在体内可抑制细胞免疫表现。我们的结果表明，α-L-岩藻糖通过局部抑制细胞免疫反应的传出阶段来抑制接触性过敏。
