巨噬细胞迁移抑制因子（MIF）膜受体上α-L-岩藻糖的需求。
Requirement for alpha-L-fucose on the macrophage membrane receptor for MIF.
作者信息
Remold H G
出版信息
J Exp Med. 1973 Nov 1;138(5):1065-76. doi: 10.1084/jem.138.5.1065.
Abstract
alpha-L-fucose abolishes the activity of guinea pig migration inhibitory factor (MIF) on the macrophages. Other sugars such as alpha-D-glucose, beta-D-galactose, alpha-L-rhamnose, methyl-alpha-D-mannoside, and N-acetyl-beta-D-glucosamine had no effect. Theabolition of MIF activity by alpha-L-fucose was reversible. When macrophages were incubated with alpha-L-fucosidase, a glycosidase which splits terminal alpha-L-fucose from oligosaccharides, the macrophages no longer responded to MIF. On the other hand, MIF incubated with alpha-L-fucosidase was still active. These experiments strongly suggest that alpha-L-fucose comprises an essential part of a macrophage membrane receptor for MIF.
摘要
α-L-岩藻糖可消除豚鼠迁移抑制因子（MIF）对巨噬细胞的活性。其他糖类，如α-D-葡萄糖、β-D-半乳糖、α-L-鼠李糖、甲基-α-D-甘露糖苷和N-乙酰-β-D-葡萄糖胺则没有作用。α-L-岩藻糖对MIF活性的消除是可逆的。当巨噬细胞与α-L-岩藻糖苷酶（一种从寡糖中裂解末端α-L-岩藻糖的糖苷酶）一起孵育时，巨噬细胞不再对MIF产生反应。另一方面，与α-L-岩藻糖苷酶一起孵育的MIF仍然具有活性。这些实验有力地表明，α-L-岩藻糖是巨噬细胞膜上MIF受体的重要组成部分。
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