Krall A, Spring-Mills E
Arch Androl. 1982 Dec;9(4):273-8. doi: 10.3109/01485018208990250.
The in vivo morphologic effects of androgen, perphenazine (a prolactin release stimulator), and bromocriptine (a prolactin release inhibitor) on the ventral prostate glands of immature intact and castrate C3H/HeJ mice were studied. Normal prostatic stromal and epithelial development was controlled by testicular androgens. Stromal proliferation and epithelial degeneration followed prepubertal castration at 21 d of age. These changes were reversed after 17-19 or 35-37 d of testosterone administration for 2 wk. In castrate mice, perphenazine administration produced near normal epithelial morphology, whereas bromocriptine stimulated principal cell hyperplasia with basal cell enlargement and increased mitotic activity. In the absence of testicular androgens, prolactin may partially control epithelial proliferation.
研究了雄激素、奋乃静（一种催乳素释放刺激剂）和溴隐亭（一种催乳素释放抑制剂）对未成熟完整和去势C3H/HeJ小鼠腹侧前列腺的体内形态学影响。正常前列腺基质和上皮的发育受睾丸雄激素控制。21日龄青春期前去势后，基质增殖和上皮变性随之发生。在给予睾酮2周，持续17 - 19天或35 - 37天后，这些变化得以逆转。在去势小鼠中，给予奋乃静可产生接近正常的上皮形态，而溴隐亭则刺激主细胞增生，伴有基底细胞增大和有丝分裂活性增加。在缺乏睾丸雄激素的情况下，催乳素可能部分控制上皮增殖。
