Christiansen S
Acta Pathol Microbiol Scand B. 1978 Oct;86B(5):267-74. doi: 10.1111/j.1699-0463.1978.tb00043.x.
A method of counting treponemes in randomly selected visual fields is described. It was found that Treponema pallidum is distributed as a Poisson distribution among the visual fields and also among samples drawn from the same suspension. Immobilized treponemes are binomally distributed among the total number of treponemes. Application of the parameters of the Poisson and the binomial distributions should be made in order to determine the dosage of T. pallidum in animal experimentation and to evaluate the outcome of the TPI test. Some statistical aspects of the investigation of treponemal survival are presented.
本文描述了一种在随机选择的视野中计数梅毒螺旋体的方法。研究发现，梅毒螺旋体在视野中以及从同一悬液中抽取的样本中均呈泊松分布。固定化的梅毒螺旋体在梅毒螺旋体总数中呈二项分布。应运用泊松分布和二项分布的参数来确定动物实验中梅毒螺旋体的剂量，并评估梅毒螺旋体制动试验的结果。文中还介绍了梅毒螺旋体存活研究的一些统计学方面。
