Klingberg F, Klingberg H
Acta Biol Med Ger. 1982;41(10):919-27.
Bilateral symmetric lesions of the anterior part of the nucleus reticularis thalami (RET) strongly reduced the preoperatively learnt avoidance responses in Long-Evans hooded rats. A great retention loss, significantly prolonged reaction times and slow incorrect escape reactions in the first postoperative session in a simple runway task were corrected in the relearning period. The relearning of directional change and of a 2:2 alternation schedule in the Y-maze was rather difficult; it delayed and remained on a lower performance level with a not correctable side preference. A great retention loss in the pole-climbing test was not compensated in the relearning period. The experimental data suggest that the RET plays an important role in the inhibition of incorrect responses.
丘脑网状核(RET)前部的双侧对称损伤显著降低了Long-Evans有帽大鼠术前习得的回避反应。在简单跑道任务中,术后第一阶段出现了严重的记忆保持丧失、反应时间显著延长以及缓慢且错误的逃避反应,这些在再学习阶段得到了纠正。Y迷宫中方向改变和2:2交替程序的再学习相当困难;它延迟了,并且在存在无法纠正的侧偏好的情况下,表现水平维持在较低水平。爬杆试验中的严重记忆保持丧失在再学习阶段没有得到弥补。实验数据表明,RET在抑制错误反应中起重要作用。