Glass J, Klingberg F
Acta Biol Med Ger. 1978;37(11-12):1693-9.
Bilateral lesions of the nucleus ventralis medialis thalami (VM) did not change the reactivity to sensory and painful stimuli, the preoperatively fixed motor patterns and the preoperatively elaborated conditioned avoidance response (CAR, jumping test) in hooded rats (Long-Evans-strain). The postoperative acquisition of a CAR in a runway was attained as in controls, but with significantly higher running speed. During continuation of the training in a Y-maze using a 2:2-alternation schedule the CAR decreased gradually to zero as a consequences of increasing reaction times (time from onset of the acoustic conditioned signal to the onset of running). At least the lesioned animals only started with the onset of the painful reinforcement. In spite of the non-avoidance these animals learned to escape correctly through the illuminated floor (dark-light-discrimination). The results are discussed as a consequence of a deficit in conditioning of locomotor programs.
对长 Evans 品系的有帽大鼠双侧丘脑腹内侧核（VM）进行损伤，并未改变其对感觉和疼痛刺激的反应性、术前固定的运动模式以及术前精心训练的条件性回避反应（CAR，跳跃试验）。术后在跑道上获得 CAR 的情况与对照组相同，但奔跑速度明显更高。在使用 2:2 交替时间表的 Y 迷宫中继续训练时，由于反应时间（从听觉条件信号开始到开始奔跑的时间）增加，CAR 逐渐降至零。至少损伤动物仅在疼痛强化开始时才开始行动。尽管没有回避行为，但这些动物学会了通过明亮地板正确逃脱（明暗辨别）。作为运动程序条件化缺陷的结果，对这些结果进行了讨论。
