Klingberg F, Klingberg H
Acta Neurobiol Exp (Wars). 1981;41(5):391-402.
Three groups each of 7 hooded rats had bilateral symmetric lesions of the n. anterior ventralis the n. anterior medialis and n. anterior dorsalis and were compared to two groups of 7 nonoperated control rats. After the lesions no changes in spontaneous behavior, sensory or motor functions, body weight, reaction type and thresholds to painful footshocks were observed. The postoperative acquisition of a one-way conditioned avoidance response in a simple runway task was significantly retarded in ventral and medial rats and impossible in dorsal rats. While escape reactions were not impaired, lesioned rats had troubles passing the start door early after the onset of the conditioned stimulus. During alternation training of avoidance responses, the ventral and the medial rats preferred one side of the Y-maze. When they learned to run to the illuminated exit as a high-probability stimulus after several sessions, the entire stereotype became more unstable and the percentage of avoidance responses decreased. None of the lesioned rats escaped shock in a pole-climbing test, which was characterized by very low probability of correct response in the first session. These anterior thalamic nuclei are part of the Papez circuit which may be the main substrate for learning and retrieval of problems with low probability.
每组7只带帽大鼠，共三组，其双侧前腹侧神经、前内侧神经和前背侧神经出现对称性损伤，并与两组各7只未手术的对照大鼠进行比较。损伤后，未观察到自发行为、感觉或运动功能、体重、反应类型以及对足部电击疼痛的阈值有任何变化。在简单跑道任务中，腹侧和内侧大鼠术后获得单向条件性回避反应的能力显著延迟，而背侧大鼠则无法获得。虽然逃避反应未受损，但损伤大鼠在条件刺激开始后早期难以通过起始门。在回避反应的交替训练中，腹侧和内侧大鼠更喜欢Y迷宫的一侧。当它们在几个训练阶段后学会跑向作为高概率刺激的 illuminated 出口时，整个刻板行为变得更加不稳定，回避反应的百分比下降。在爬杆试验中，没有一只损伤大鼠能躲避电击，该试验的特点是在第一阶段正确反应的概率非常低。这些丘脑前核是Papez回路的一部分，Papez回路可能是学习和检索低概率问题的主要基质。 （注：原文中“illuminated”可能有误，推测应为“illuminating”之类，这里按原文翻译）
