Steinemann M
Chromosoma. 1982;86(1):59-76. doi: 10.1007/BF00330730.
Drosophila miranda possesses an intriguing sex chromosome constitution. While female metaphase plates have 10 chromosomes (diploid set), in males only 9 chromosomes can be identified. The missing homologue has been translocated to the Y, forming a neo-Y chromosome which is polytenized in the salivary gland cells. This report presents a detailed characterization of DNA, isolated from D. miranda flies. In situ hybridizations, using cRNA transcribed from unfractionated D. miranda DNA, reveal hybridization to the neo-Y with label distributed over the entire chromosome. The original partner of the translocated chromosome, X2, is essentially unlabelled. These results suggest that repetitive DNA sequences "invade" the translocated chromosome. This result is discussed with reference to the hypothesis of "degeneration" of the Y chromosome, formulated by Muller (1918, 1932a).
拟果蝇具有一种有趣的性染色体组成。雌性中期板有10条染色体（二倍体组），而雄性只能识别出9条染色体。缺失的同源染色体已易位到Y染色体上，形成了一条在唾液腺细胞中多线化的新Y染色体。本报告详细描述了从拟果蝇中分离出的DNA的特征。使用从未分级的拟果蝇DNA转录的cRNA进行原位杂交，结果显示与新Y染色体杂交，标记分布在整个染色体上。易位染色体的原始伙伴X2基本上没有标记。这些结果表明重复DNA序列“侵入”了易位染色体。结合穆勒（1918年、1932年a）提出的Y染色体“退化”假说对这一结果进行了讨论。
