Rabinovitch B, March W F, Adams R L
Diabetes Care. 1982 May-Jun;5(3):254-8. doi: 10.2337/diacare.5.3.254.
We have described the concept of using the aqueous humor glucose as a measure of the blood glucose concentration, with a view to developing a noninvasive glucose monitor for diabetic individuals. We have conceived of a scleral lens that houses a light source, polarizers, other electro-optic units, and a light detector, and which measures the optical rotation of the aqueous humor continuously. We have built an optical bench mock-up of the glucose sensor and assessed the limits of its capabilities. We have described a physical method, employing the Faraday effect, that modulates the incident light and uses a compensator to introduce a feedback mechanism giving a null-point technique capable of measuring extremely small rotations with an accuracy of 0.4 s of arc. We have used this and have measured the optical rotations of glucose solutions from 0.02 to 0.1%, and have demonstrated linearity in both cases. Miniaturization of the technique is discussed.
我们已经描述了利用房水葡萄糖来测量血糖浓度的概念，旨在为糖尿病患者开发一种非侵入性血糖监测仪。我们构思了一种巩膜透镜，它容纳光源、偏振器、其他电光单元和光探测器，并能连续测量房水的旋光度。我们搭建了葡萄糖传感器的光学平台模型，并评估了其性能极限。我们描述了一种利用法拉第效应的物理方法，该方法调制入射光并使用补偿器引入反馈机制，实现一种零点技术，能够以0.4弧秒的精度测量极小的旋转。我们已运用此方法测量了浓度从0.02%到0.1%的葡萄糖溶液的旋光度，并在两种情况下都证明了线性关系。文中还讨论了该技术的小型化问题。
