抗凝血酶III抑制α-凝血酶的两步反应机制的证明以及受肝素影响步骤的鉴定。 - Suppr

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Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin.

作者信息

Olson S T, Shore J D

出版信息

J Biol Chem. 1982 Dec 25;257(24):14891-5.

PMID:7174671

Abstract

摘要

相似文献

Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin.抗凝血酶III抑制α-凝血酶的两步反应机制的证明以及受肝素影响步骤的鉴定。

J Biol Chem. 1982 Dec 25;257(24):14891-5.

Inhibition of esterase and amidase activities of alpha- and beta-thrombin in the presence of antithrombin III and heparin.在抗凝血酶III和肝素存在的情况下，α-和β-凝血酶酯酶及酰胺酶活性的抑制作用

Biochim Biophys Acta. 1979 Feb 9;566(2):385-9. doi: 10.1016/0005-2744(79)90042-1.

The heparin-enhanced antithrombin III/thrombin reaction is saturable with respect to both thrombin and antithrombin III.肝素增强的抗凝血酶III/凝血酶反应对于凝血酶和抗凝血酶III而言都是可饱和的。

J Biol Chem. 1982 Dec 10;257(23):13899-302.

Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. The reaction step limiting heparin turnover in thrombin neutralization.

J Biol Chem. 1986 Oct 5;261(28):13151-9.

Calcium inhibits the heparin-catalyzed antithrombin III/thrombin reaction by decreasing the apparent binding affinity of heparin for thrombin.钙通过降低肝素对凝血酶的表观结合亲和力来抑制肝素催化的抗凝血酶III/凝血酶反应。

Arch Biochem Biophys. 1983 Sep;225(2):958-63. doi: 10.1016/0003-9861(83)90111-x.

A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin.一个描述抗凝血酶III与凝血酶之间肝素催化反应动力学的简单速率定律。

J Biol Chem. 1983 Dec 10;258(23):14708-17.

The influence of heparin, NaCl and CaCl2 on the rate of the thrombin-antithrombin III reaction.肝素、氯化钠和氯化钙对凝血酶 - 抗凝血酶III反应速率的影响。

Thromb Res. 1979;15(5-6):821-34. doi: 10.1016/0049-3848(79)90191-9.

Heparin-catalyzed inhibitor/protease reactions: kinetic evidence for a common mechanism of action of heparin.肝素催化的抑制剂/蛋白酶反应：肝素作用共同机制的动力学证据

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5460-4. doi: 10.1073/pnas.80.18.5460.

The heparin-accelerated neutralisation of bovine alpha and beta thrombins by antithrombin III.抗凝血酶III对牛α和β凝血酶的肝素加速中和作用。

Biochim Biophys Acta. 1980 Sep 17;632(1):131-7. doi: 10.1016/0304-4165(80)90256-1.

Involvement of heparin chain length in the heparin-catalyzed inhibition of thrombin by antithrombin III.抗凝血酶III介导的肝素链长度对肝素催化抑制凝血酶的影响

J Biol Chem. 1984 May 10;259(9):5670-7.

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