DeLuca J, Hardy C A, Burright R G, Donovick P J, Tuggy R L
J Toxicol Environ Health. 1982 Sep;10(3):441-7. doi: 10.1080/15287398209530266.
To examine the effects of dietary fat on the levels of lead in the blood, 34-40-d-old male mice were fed normal or high-fat diets along with distilled water for an initial 48-h exposure period. Following this session, subjects from each diet condition were administered either 0, 0.075, or 0.5% lead acetate through the drinking water during the next 48 h along with their respective diets. Atomic absorption was used to analyze blood-lead levels. At each concentration of lead, the high-fat diet increased the blood lead content over subjects fed the control diet. The highest blood lead levels were found in the 0.5% lead acetate, high-fat diet condition. The importance of nutritional considerations in understanding lead toxicity is discussed.
为研究膳食脂肪对血液中铅水平的影响，将34至40日龄的雄性小鼠在最初48小时的暴露期内喂食正常或高脂肪饮食并同时饮用蒸馏水。在此阶段之后，在下一个48小时内，给每种饮食条件下的小鼠通过饮用水分别给予0、0.075或0.5%的醋酸铅，同时继续给予各自的饮食。采用原子吸收法分析血铅水平。在每个铅浓度下，与喂食对照饮食的小鼠相比，高脂肪饮食均增加了血铅含量。在0.5%醋酸铅、高脂肪饮食条件下发现血铅水平最高。文中讨论了营养因素在理解铅毒性方面的重要性。
