Pfister W, Sprössig M, Wachtel D, Mirgorod M, Gängler P
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1982 Sep;252(4):540-6.
Before and 4 weeks after a single course of local treatment, the composition of subgingival microflora of 15 patients with marginal periodontitis was determined by cultural and microscopical examination. A significant reduction in the number of gram-negative microorganisms could be achieved by this treatment. Anaerobic sporeless rods like Bacteroides and Fusobacteria but also Spirochetes, Eikenella and Capnocytophaga were involved in the inflammation. The number of Actinomyces in the subgingival flora was also significantly reduced by therapy. After treatment the number of gram-positive bacteria like Streptococci and Corynebacteria was significantly increased. The reduction in the number of these gram-negative bacteria in line with the reduction of periodontal inflammation is a criterion of their significance in the etiology of marginal periodontitis.
在对15例边缘性牙周炎患者进行单疗程局部治疗前及治疗后4周，通过培养和显微镜检查确定龈下微生物群落的组成。该治疗可使革兰氏阴性微生物数量显著减少。诸如拟杆菌属和梭杆菌属等厌氧无芽孢杆菌，以及螺旋体、艾肯菌属和二氧化碳嗜纤维菌属都与炎症有关。治疗后龈下菌群中放线菌的数量也显著减少。治疗后，链球菌和棒状杆菌等革兰氏阳性菌的数量显著增加。这些革兰氏阴性菌数量的减少与牙周炎症的减轻相一致，这是它们在边缘性牙周炎病因学中具有重要意义的一个标准。
