Alm J, Hagenfeldt L, Larsson A
Ann Clin Biochem. 1978 Sep;15(5):245-9. doi: 10.1177/000456327801500159.
Urine concentrations of organic acids were determined by a gas chromatographic technique in healthy, full-term neonates at the ages of 2 and 5 days. Significant reductions in the interindividual variation were obtained by relating the levels of organic acids to urine creatinine concentration or osmolality. Citrate was the predominant organic anion found. Urine concentrations of fumarate, 3-hydroxy-3-methylglutarate, adipate, and suberate decreased during the first week of life, and their concentrations were significantly intercorrelated. It is suggested that these findings reflect the predominantly fat-utilising, hyperketonaemic state during the first days of life. The urine concentrations of the aromatic end-products, p-hydroxyphenylacetate and hippurate, increased during the first week of life, probably as an effect of dietary factors. It is concluded that analysis of intermediary organic acids in urine could be of value in the assessment of the metabolic state in neonates.
采用气相色谱技术测定了2日龄和5日龄健康足月新生儿尿液中有机酸的浓度。通过将有机酸水平与尿肌酐浓度或渗透压相关联，个体间差异显著降低。柠檬酸是发现的主要有机阴离子。富马酸盐、3-羟基-3-甲基戊二酸盐、己二酸盐和辛二酸盐的尿液浓度在出生后第一周下降，且它们的浓度之间存在显著的相互关联。提示这些发现反映了出生后最初几天以脂肪利用为主的高酮血症状态。芳香族终产物对羟基苯乙酸和马尿酸的尿液浓度在出生后第一周增加，可能是饮食因素的影响。结论是，尿液中中间有机酸的分析可能对评估新生儿的代谢状态有价值。
