Elliott G R, Peterson P K, Verbrugh H A, Freiberg M R, Hoidal J R, Quie P G
Antimicrob Agents Chemother. 1982 Nov;22(5):781-4. doi: 10.1128/AAC.22.5.781.
After an initial 2-h incubation with phagocytic cells, the growth of surviving intracellular Staphylococcus aureus was examined in the presence of subinhibitory concentrations of penicillin, cephalothin, and clindamycin. One-tenth of the minimal inhibitory concentrations of these antibiotics markedly reduced bacterial growth in normal polymorphonuclear leukocytes. In contrast, when human alveolar macrophages were studied, no inhibition of growth was seen. Subinhibitory concentrations of these antibiotics and polymorphonuclear leukocytes acted synergistically to reduce intracellular survival of S. aureus. This synergy did not appear to be dependent upon the microbicidal potential of the leukocyte respiratory burst, since no differences were found when polymorphonuclear leukocytes obtained from patients with chronic granulomatous disease were compared with those from normal donors.
在与吞噬细胞进行初始2小时的孵育后，在亚抑菌浓度的青霉素、头孢噻吩和克林霉素存在的情况下，检测存活的细胞内金黄色葡萄球菌的生长情况。这些抗生素最低抑菌浓度的十分之一显著降低了正常多形核白细胞中的细菌生长。相比之下，在研究人肺泡巨噬细胞时，未观察到生长抑制。这些抗生素的亚抑菌浓度与多形核白细胞协同作用以降低金黄色葡萄球菌的细胞内存活率。这种协同作用似乎不依赖于白细胞呼吸爆发的杀菌潜力，因为将慢性肉芽肿病患者的多形核白细胞与正常供体的多形核白细胞进行比较时未发现差异。
