Carter D M, Wolff K, Schnedl W
J Invest Dermatol. 1976 Oct;67(4):548-51. doi: 10.1111/1523-1747.ep12664558.
8-Methoxypsoralen (8-MOP) and long-wave UV light (UVA 365 nm) are now being use to treat vitiligo and psoriasis. Cultured human lymphocytes exposed to these agents in vitro show an increased infrequency of sister chromatid exchanges, related to 8-MOP-DNA photoadducts. Although these data raise questions regarding the biologic consequences of this therapeutic regimen, it is unknown whether 8-MOP and UVA cause mutations or extracutaneous somatic cell recombinants in vivo. Exchanges may represent cellular repair of DNA damage.
8-甲氧基补骨脂素（8-MOP）和长波紫外线（UVA 365纳米）目前正用于治疗白癜风和银屑病。体外培养的人类淋巴细胞暴露于这些药剂时，姐妹染色单体交换频率增加，这与8-MOP-DNA光加合物有关。尽管这些数据引发了关于这种治疗方案生物学后果的疑问，但8-MOP和UVA在体内是否会导致突变或皮肤外体细胞重组尚不清楚。交换可能代表DNA损伤的细胞修复。
