Fischbein A, Thornton J C, Sarkozi L, Kon S, Levin S
J Appl Toxicol. 1982 Dec;2(6):289-93. doi: 10.1002/jat.2550020605.
In an attempt to identify health effects associated with low-level lead exposure, 45 cable-manufacturing workers underwent clinical examinations in a cross-sectional study. Thirteen workers were in direct contact with lead-containing stabilizers, while 31 were only indirectly exposed. The directly exposed had a higher prevalence of reported neurological and gastrointestinal symptoms than those with low or insignificant lead exposure. None of the directly exposed had blood lead levels exceeding 60 micrograms per 100 ml. The clinical symptoms correlated with blood lead and zinc protoporphyrin. However, when the data were subjected to hierarchical log-linear modeling, a partial association was found between zinc protoporphyrin and symptoms, but not between blood lead and symptoms. The data suggest that non-specific neurological and gastrointestinal symptoms may occur at relatively low blood lead and zinc protoporphyrin levels, and that measurement of zinc protoporphyrin and exploration of clinical symptoms are valuable components in lead screening programs.
为了确定与低水平铅暴露相关的健康影响，45名电缆制造工人在一项横断面研究中接受了临床检查。13名工人直接接触含铅稳定剂，31名工人仅间接暴露。直接暴露的工人报告的神经和胃肠道症状患病率高于低铅暴露或无显著铅暴露的工人。直接暴露的工人中没有一个血铅水平超过每100毫升60微克。临床症状与血铅和锌原卟啉相关。然而，当数据进行分层对数线性建模时，发现锌原卟啉与症状之间存在部分关联，但血铅与症状之间不存在关联。数据表明，在相对较低的血铅和锌原卟啉水平下可能会出现非特异性神经和胃肠道症状，并且锌原卟啉的测量和临床症状的探查是铅筛查项目中的重要组成部分。
