Williams R S, Logue E E, Lewis J G, Barton T, Stead N W, Wallace A G, Pizzo S V
N Engl J Med. 1980 May 1;302(18):987-91. doi: 10.1056/NEJM198005013021802.
The effects of a 10-week physical-conditioning program on fibrinolytic activity at rest and after stimulation by venous occlusion were studied in 69 healthy adults 25 to 69 years old. Physical conditioning was documented by treadmill performance, and fibrinolysis was measured with a newly developed radioenzymatic assay. Whereas fibrinolysis declined at rest from 16.2 +/- 1.3 to 11.4 +/- 0.8 units (mean +/- S.E.M.) (P = 0.0017), the increment in fibrinolysis produced by venous occlusion was increased from 21.7 +/- 2.9 to 33.8 +/- 4.7 units (P = 0.0037). This augmentation was most marked in women, persons with low initial levels of stimulated fibrinolysis, and persons with low initial physical fitness. We conclude that physical conditioning can enhance the augmentation of fibrinolytic activity that occurs in response to venous occlusion. Enhanced fibrinolysis in response to thrombotic stimuli could be an important mechanism in the beneficial effect of habitual physical activity on the risk of cardiovascular disease.
在69名年龄在25至69岁的健康成年人中，研究了为期10周的体能训练计划对静息状态下以及静脉阻塞刺激后的纤溶活性的影响。通过跑步机运动表现记录体能训练情况，并用新开发的放射酶测定法测量纤溶作用。静息时纤溶活性从16.2±1.3单位降至11.4±0.8单位（平均值±标准误）（P = 0.0017），而静脉阻塞引起的纤溶活性增加量从21.7±2.9单位增至33.8±4.7单位（P = 0.0037）。这种增强在女性、静息纤溶活性初始水平较低的人以及初始体能较差的人中最为明显。我们得出结论，体能训练可增强因静脉阻塞而发生的纤溶活性增强。对血栓形成刺激的纤溶增强可能是习惯性体力活动对心血管疾病风险产生有益影响的重要机制。
