Mueller-Eckhardt C, Lechner K, Heinrich D, Marks H J, Mueller-Eckhardt G, Bettelheim P, Breithaupt H
Blut. 1980 Apr;40(4):249-57. doi: 10.1007/BF01080184.
Two patients with post-transfusion thrombocytopenic purpura are described, the first cases recognized in Austria and Germany. Both patients were female, 51 and 60 years of age. The purpura was evoked by blood transfusions with a latent period of 2 and 7 days. The thrombocytopenic episode lasted for 22 and 60 days. In one case, thrombocytopenia was associated with agranulocytosis due to transient bone marrow failure. Both patients were negative for the platelet-specific antigen PlA1 (= ZWa). Their sera contained PlA1 as well as potent HLA antibodies. Detailed clinical and serological data are presented. The literature with a total of 25 cases so far reported is surveyed.
本文描述了两名输血后血小板减少性紫癜患者，这是奥地利和德国首次确诊的病例。两名患者均为女性，年龄分别为51岁和60岁。紫癜由输血诱发，潜伏期分别为2天和7天。血小板减少发作持续了22天和60天。其中一例患者的血小板减少与因短暂性骨髓衰竭导致的粒细胞缺乏症有关。两名患者的血小板特异性抗原PlA1（= ZWa）均为阴性。她们的血清中含有PlA1以及强效的HLA抗体。文中呈现了详细的临床和血清学数据。并对目前已报道的共25例病例的文献进行了综述。
